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Human results are not established, and large human trials have not been completed, which is a critical limit to keep in mind

However, increased potency requires vigilance

Managing GI side effects and titration strategies Gastrointestinal adverse events affect 40-70% of treated patients [25], primarily consisting of: Nausea (15-50%) Diarrhea (5-25%) Vomiting (5-10%) Slow titration remains fundamental to mitigating these effects

Oxidative stress was indicated by MDA, as a consequence of the lipid peroxidation process because it was produced excessively when there was an increase in free radicals (Dodda et al